Layer-by-layer nucleation mechanism for quantum dot formation in strained heteroepitaxy

2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

A Microcantilever-based Gas Flow Sensor for Flow Rate and Direction Detection

The purpose of this paper is to apply characteristics of residual stress that causes cantilever beams to bend for manufacturing a micro-structured gas flow sensor. This study uses a silicon wafer deposited silicon nitride layers, reassembled the gas flow sensor with four cantilever beams that perpendicular to each other and manufactured piezoresistive structure on each micro-cantilever by MEMS technologies, respectively. When the cantilever beams are formed after etching the silicon wafer, it bends up a little due to the released residual stress induced in the previous fabrication process. As air flows through the sensor upstream and downstream beam deformation was made, thus the airflow direction can be determined through comparing the resistance variation between different cantilever beams. The flow rate can also be measured by calculating the total resistance variations on the four cantilevers.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

A Game of Attribute Decomposition for Software Architecture Design

Attribute-driven software architecture design aims to provide decision support by taking into account the quality attributes of softwares. A central question in this process is: What architecture design best fulfills the desirable software requirements? To answer this question, a system designer needs to make tradeoffs among several potentially conflicting quality attributes. Such decisions are normally ad-hoc and rely heavily on experiences. We propose a mathematical approach to tackle this problem. Game theory naturally provides the basic language: Players represent requirements, and strategies involve setting up coalitions among the players. In this way we propose a novel model, called decomposition game, for attribute-driven design. We present its solution concept based on the notion of cohesion and expansion-freedom and prove that a solution always exists. We then investigate the computational complexity of obtaining a solution. The game model and the algorithms may serve as a general framework for providing useful guidance for software architecture design. We present our results through running examples and a case study on a real-life software project.Comment: 23 pages, 5 figures, a shorter version to appear at 12th International Colloquium on Theoretical Aspects of Computing (ICTAC 2015

Self-assembled nanostructures in strained heteroepitaxy

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Island, pit, and groove formation in strained heteroepitaxy

2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Plan de negocio de un centro de recreaci?n e integraci?n para el adulto mayor en Lima Metropolitana - Lima Norte

El presente trabajo ?Plan de Negocio de Centro de Recreaci?n e Integraci?n para el Adulto Mayor en Lima Metropolitana? plantea como principal objetivo el dise?ar un modelo de negocio que potencie las habilidades f?sicas motoras del adulto mayor a trav?s de los diversos programas. El trabajo resulta como parte de la investigaci?n de la demanda realizada en Lima Norte. El proyecto se dise?? para un horizonte de 10 a?os, considerando una inversi?n inicial aproximada de 230,000 soles. Por el monto de la inversi?n este puede ser cubierto con capital propio no teniendo necesidad de recurrir a un financiamiento bancario. A trav?s del estudio de mercado (encuestas en las zonas de inter?s) se determin? que el servicio podr?a ser ofrecido a personas que van de los 60 a 75 a?os en promedio, servicios que podr?n ser pagados por pagos mensuales por los usuarios del centro. El an?lisis financiero ha determinado que el negocio generar?a ingresos desde el d?cimo primer mes, entonces en 10 a?os se estima que la utilidad neta ser? aproximadamente de 4,250,000 soles, lo que determina que el negocio es rentable con un TIR de 54% y un VAN de 550,000

Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality

published_or_final_versio

Precise Neutron Magnetic Form Factors

Precise data on the neutron magnetic form factor G_{mn} have been obtained with measurements of the ratio of cross sections of D(e,e'n) and D(e,e'p) up to momentum transfers of Q^2 = 0.9 (GeV/c)^2. Data with typical uncertainties of 1.5% are presented. These data allow for the first time to extract a precise value of the magnetic radius of the neutron.Comment: 10 pages, 2 figures, submitted to Physics Letters

Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells

INTRODUCTION: Cyclin E, a G(1 )cyclin essential for G(1)–S phase transition, is known to have a profound effect on tumorigenesis. Elevated levels of cyclin E have been associated with breast cancer, and chromosomal instability observed in breast cancer is suggested to be associated with constitutive expression of cyclin E. It was previously demonstrated that SUM149PT human breast cancer cells show very high levels of cyclin E expression by western analysis and that they express a nonfunctional cyclin E ubiquitin ligase due to a mutation in the F-box protein hCdc4. METHODS: We examined cyclin E expression in both MCF10A and SUM149PT cells using western blot analysis and flow cytometry. Immunofluorescence was utilized for the localization of cyclin E in both normal and breast cancer cells. In addition, array comparative genomic hybridization analysis was performed to compare chromosome copy number alterations with levels of cyclin E expression among a panel of breast cancer cell lines. RESULTS: SUM149PT cells overexpress cyclin E on a cell per cell basis for the duration of the cell cycle. High cyclin E levels are maintained throughout the S phase, and SUM149PT cells exhibit an S phase delay or arrest probably due to cyclin E overexpression. In addition, comparative genomic hybridization indicated that SUM149PT cells exhibit many chromosome copy number alterations, which may reflect prior or ongoing genomic instability. However, no direct correlation was observed between cyclin E levels and genomic copy number alteration in a panel of human breast cancer cell lines. CONCLUSIONS: Cyclin E is overexpressed at high levels throughout the cell cycle in SUM149PT cells, which is in stark contrast to cyclin E degradation observed in the mid to late S phase of normal cells. SUM149PT cells are unable to regulate cyclin E and also exhibit many copy number alterations. However, there was a lack of direct correlation between cyclin E overexpression and chromosomal instability across a panel of other breast cancer cell lines examined